Two Blades Foundation

 Please address any inquiries to:

Two Blades Foundation

1630 Chicago Avenue

Suite 1907

Evanston, IL 60201


+1 847 425 1277

Latest News:

November 9, 2015

2Blades and United Genetics have completed a non-exclusive license agreement for the use of the pepper bs5 gene for marker assisted selection in pepper breeding.

September 15, 2015

The Gordon and Betty Moore Foundation has awarded 2Blades a $2.3 million grant to examine the diversity of resistance genes in plants.  The effort is a collaboration with the laboratories of Jeff Dangl, Jonathan Jones, Brian Staskawicz, and Detlef Weigel, internationally renowned leaders in the field.  Results of the study will both enhance the understanding of evolutionary processes and provide new insights into improving plant immunity and reducing crop disease. 

Press release

September 10, 2015

2Blades announces that it was awarded a funding contract from the Citrus Research and Development Foundation in support of work to develop resistance to citrus canker, a major disease of citrus in Florida and globally.  2Blades will test multiple genetic approaches to Xanthomonas resistance in collaboration with researchers at the University of California, Berkeley, and at the University of Florida.

August 4, 2015

2Blades completed a non-exclusive license with Bejo Zaden to provide Bejo with access to the bs5 disease resistance gene from pepper for use in their conventional breeding program.

December 18, 2014

2Blades and Cellectis plant science announce completion of a non-exclusive cross-licensing agreement on TAL nuclease technologies.  Each organization has exclusive rights to issued and pending patents covering aspects of this precise gene editing technology, and cross-licensing will streamline the delivery of benefits to agriculture.

Press release

December 16, 2014

2Blades is pleased to announce that Jacqueline Heard will join 2Blades as CEO in January, 2015.  Dr. Heard was an Investment Director at Monsanto Growth Ventures.

Press release

August 7, 2014

2Blades applauds the spectacular initial success of the experimental ebola therapy made in plants, developed by former "Blade" Michael Pauly and colleagues at Mapp Biopharmaceutical:

Link to New York Times article

July 28, 2014

2Blades has granted a non-exclusive license to Pepper Research for the sequence of the pepper disease resistance gene, bs5, for use in breeding bacterial spot resistant pepper varieties.

July 21, 2014

2Blades and Sakata Seed have completed a non-exclusive license to the sequence of the pepper disease resistance gene, bs5.  The agreement provides Sakata with rights to use the gene sequence and markers in conventional breeding of peppers to develop Xanthomonas-resistant varieties. Bacterial spot disease, caused by Xanthomonas infection, is a major production limitation of both pepper and tomato worldwide.  2Blades has supported the development of a number of resistance approaches and aims to get these into broad use for commercial and subsistence agriculture.

April 16, 2014

2Blades warmly welcomes new Program Director Lynne Reuber to our organization. Dr. Reuber joins us from Mendel Biotechnology, where she served as Director of Research.

February 5, 2014

The Plant Management Network posted an educational webcast about bacterial spot-resistant tomatoes carrying the pepper Bs2 gene today as part of their Focus on Tomato series:

Bacterial Leaf Spot Resistance presentation

February 3, 2014

2Blades and DuPont Pioneer announce a research collaboration to develop durable resistance against Asian Soybean Rust with partners at the Universidade Federal de Vicosa in Brazil and The Sainsbury Laboratory in Norwich, UK.

Press release

August 15, 2013

Science today published on-line a review on the progress and potential for deploying disease resistance in crop plants in a special issue on smarter pest control.  The review focuses on the developments in the understanding of plant resistance mechanisms, the status of efforts to apply this knowledge to minimize crop losses, and new approaches to improving the ages-old practice of breeding for disease resistance.

June 25, 2013

2Blades announces that a second patent in 2Blades' TAL Code patent estate issued today.   U.S. Pat. No. 8,470,973 is directed to methods of modifying genomes using TAL effector-endonucleases.

May 13, 2013

2Blades announces that the first TAL effector patent issued on April 16, 2013.   U.S. Pat. No. 8,420,782, is directed to TAL effectors with endonuclease activity and is the first issuing patent of a comprehensive estate of patent applications.

Press release

April 9, 2013

Useful open resource for plant resistance genes:

April 3, 2013

2Blades is delighted to welcome Professor Sir David Baulcombe to our Scientific Advisory Board. 

December 10, 2012

2Blades continues broad license access to its award-winning TAL technology through a non-exclusive license to Dupont Pioneer for uses in certain crops.
Improvements to the technology will be granted back for 2Blades' humanitarian projects benefiting subsistence farming.

Press release

November 7, 2012

2Blades' TAL Code technology wins 2012 Agrow Award for Best Novel Agricultural Biotechnology.

Agrow Awards site

October 9, 2012

2Blades has signed a non-exclusive license with Mendel Biotechnology for the TAL code technology.

Press release

September 11, 2012

2Blades collaborator Prof. John Scott of the University of Florida presented trial results on transgenic disease-resistance in Florida tomato varieties last week at the annual Tomato Institute meeting.  Scott presented the improved performance of parent and hybrid lines containing the pepper gene Bs2, as compared to the same lines without the gene and widely grown commercial varieties, in the presence of endemic bacterial spot infection.  These results were highlighted in an interview in The Packer:

Transgenic tomato withstands bacterial spot, yields more fruit

September 4, 2012

2Blades announces the expansion of rights to Monsanto under our non-exclusive license, announced in April, 2012, for broader access to the TAL Code technology.  2Blades will continue to receive a grant back of improvements to the technology for use in 2Blades’ humanitarian projects.

Press release

August 1, 2012

Results of tomato field trials demonstrating bacterial spot resistance and yield improvement were published today at PLOS ONE:
Transgenic resistance confers effective field level control of bacterial spot disease in tomato

July 9, 2012

2Blades announces the completion of a non-exclusive license with KWS for access to the TAL Code technology.  KWS will grant improvements in the technology back to 2Blades for subsistence farming applications.

Press release

May 1, 2012

2Blades is pleased to announce completion of a non-exclusive license agreement with Bayer CropScience for the TAL code genome engineering technology.  2Blades will receive improvements to the TAL code for use in its subsistence farming applications.

Press release

April 16, 2012

Monsanto has completed a non-exclusive license with 2Blades for commercial uses of the TAL Code technology in plants.  Improvements to the technology will be granted back for 2Blades' humanitarian projects benefiting subsistence farming.

Press release

March 19, 2012

Services for TAL effector-based research tools were launched today by Life Technologies.

Press release from Life Technologies


January 16, 2012

2Blades announces the signing of a non-exclusive license for the TAL Code technology to Syngenta for commercial uses in crop plants.  Syngenta will grant 2Blades access to its improvements to the technology for use in 2Blades’ humanitarian efforts to support subsistence farming.

Press release

June 10, 2011

2Blades announces the licensing of the plant rights for the TAL Effector Code to Life Technologies for research tool applications.  The exclusive license, made jointly with the technology inventors, will enable Life Technologies to develop research tools for all applications, as well as for commercial non-plant uses.  2Blades retains the rights for commercial applications in plants and green algae and intends to make licenses broadly available.

Press release from Life Technologies

August 1, 2010

2Blades is delighted to announce the addition of Jim Carrington to our Science Advisory Board.

March 15, 2010

New defenses deployed against plant diseases:

July 20, 2009

2Blades and The Sainsbury Laboratory partner to enhance the translation of fundamental discoveries in plant-pathogen interactions into practical applications in the field: